Minnesota-born Brianna Brown began acting in elementary school and local community productions. After high school she journeyed to Hollywood to pursue an acting career full-time. She snagged a part in the pilot show for Judd Apatow's quirky, fondly remembered series Freaks & Geeks (1999). From there she got parts in several theatrical features, mostly comedies, and in 2004 secured a part in Spider-Man 2 (2004). She worked steadily over the next few years, playing everything from a farmer's wife to a killer of zombies (Nuit des morts-vivants 3D (2006)), and worked again for Apatow in two more of his comedies, 40 ans, toujours puceau (2005) and En cloque, mode d'emploi (2007).
She also kept busy with guest-starring roles on some of the top series on TV, such as Les experts: Miami (2002), FBI - Portés disparus (2002), Smallville (2001) and had a memorable turn as a serial-killing call girl in Esprits criminels (2005). She had a long-running part on the soap Hôpital central (1963) as Dr. Lisa Miles.
Outside the film industry, she has been involved in giving women the opportunity to empower themselves financially, co-founding the "Green Goddess Investment Club" and starting a womens group called "The New Hollywood Womens Goal Group".
