Serinda always had her eye on acting. Her mother, an actress, would frequently take her, on set, when she was little. When she was three years old, she starred in her first motion picture, Cousins (1989), with Ted Danson and Isabella Rossellini, when director Joel Schumacher personally chose her.
Since that time, she has appeared in commercials for "Milky Way", "Much Music", "Macy's" and "Absolute Poker" (where she has been named as spokesperson), among others. She has also appeared in television shows, such as Blood Ties (2006), Supernatural (2005) and Smallville (2001), and movies, such as La terreur du Loch Ness (2008) and Neal 'N' Nikki (2005).
In addition, she is also involved in modeling. For example: she is one of the faces of Guess? watches, having beaten out over 75,000 competitors.
Serinda continues to balance both her acting and modeling careers, although she prefers acting.
As of 2011, she portrays "Erica Reed" on the A&E Drama, Breakout Kings (2011), in her first starring role.
